Have you run 'sh /script/fixmail-all; qmailctl restart'. Better reboot instead restart.
Update without reboot made my server not work for received and sent mail. But, after reboot all functions back to normal.
If your server not work before update maybe need drastic process:
yum remove *-toaster
rm -rf /var/qmail/*
yum install *-toaster
yum install cronie cronie-anacron crontabs webalizer.
sh /script/fixmail-all
reboot