I have server with 96GB and install with Centos 6 64bit + Kloxo-MR 7.0. No issue until now.
I've lowered vm.min_free_kbytes from 1 million to 0,5 milion
vm.zone_reclaim_mode = 1
vm.min_free_kbytes=512000
vm.vfs_cache_pressure=200
kernel.sem = 250 32000 100 128
### begin -- add by Kloxo-MR
fs.aio-max-nr = 1048576
fs.file-max = 1048576
net.ipv4.tcp_syncookies = 1
net.ipv4.tcp_max_syn_backlog = 2048
vm.swappiness = 10
#vm.vfs_cache_pressure = 100
#vm.dirty_background_ratio = 15
#vm.dirty_ratio = 5
### end -- add by Kloxo-MR